Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

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The mucoepidermoid carcinoma generally shows an extremely aggressive glandulxs for high-grade tumors, whereas its respectivee low-grade counterpart is often indolent and slow-growing.

The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood. There have been suggestions that the overexpression of c-erbB-2 on salivary gland tumors is related with histogenesis of these lesions Glisson et al.

Complementary studies to compare carbohydrates of the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence their biological behavior.

Cytoplasmic expression was also observed but not considered in this study as reported in diverse salivary gland tumors Kernohan et al. Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival.

Carcinoma mucoepidermoide

The follow-up period in this study ranged from 6 to months. A total of 16 cases were analyzed over a period of 18 years; males were This provides further support to the existence of distinct molecular mechanisms in salivary gland carcinogenesis associated with the overexpression of c-erbB In 2 cases of low grade cholesterol clefts, macrophages and foreign-body giant cells were observed.


Microscopically, 27 cases Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, Data concerning survival recurrence and metastasis were evaluated. Mucoepidermoid Carcinoma of Salivary Glands: Few papers evaluating only one type of oral salivary gland tumors are available. Surgical Pathology ofthe salivary glands.

For this study only the intraoral MEC surgically treated with adequate material for microscopic and immunohistochemical analysis corresponding to 29 cases were analyzed.

The tumoral histological grade was associated with the ki67 expression, relevant prognosis factors in MEC. The medical and surgical records of all cases were reviewed for clinicopathological factors, such as age, gender, primary tumor location, tumor size, clinical stage, histological grade, treatment, compromised surgical margins, tumor recurrence, metastasis, disease-free survival DFS and overall survival OS.

It is composed of mucous, epidermoid, intermediate, columnar and clear cells. Mucoepidermoid carcinoma of the salivary glands in Brazil: All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Carcinoma of the parotid and submandibular glands a study of survival in patients. Otolaryngol Head Zalivales Surg. Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. Mucoepidermoid carcinoma of intraoral salivary gglandulas. The parotid was the most affected gland, followed by the palate and sub maxillary, which agree with the bibliography. This antibody although less sensitive than the polyclonal antibody used in other reports Lopes et al.

Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al.


Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

Published works usually lose relevant survival information through time. Histological and Inmunohistochemical Prognostic Factors. This overexpression may be due to the process envolving histogenesis and celular differentiation. Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al.

MEC is reported to manifest variable biologic aggressiveness, basically showing correlation with its histological features and is graded by a 3-tiered system Auclair et al, Salivary gland tumors in children and adolescents: P; Quattrone, P; Cantu, G. Cytoplasmic expression of c-erbB2 in non-small cell lung cancers.

MEC is composed of varying proportions of mucous, epidermoid, columnar, intermediate and clear cells Auclair et al. However, its prognostic value should be validated with clinical studies and survival analyses.

Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at earlier stages, probably due to the less aggressive growth in addition to a better visible tumor site.

In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS.