LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]. Gene ID: , updated on 7-Dec This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated . Leucine-rich repeat transmembrane neuronal protein 1. Gene. Lrrtm1. Organism. Mus musculus (Mouse). Status. Reviewed-Annotation score: Annotation.
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In a recent meta-analysis of 20 linkage screens for schizophrenia, 2p12—q22 was the only location to reach significance when adjusted for genome-wide testing.
We genotyped rs almost tagging for the risk haplotype; Figure S1in two case—control collections of European descent cases and controls from Munich, Germany, and cases and controls from Scotland all cases had Diagnostic and Statistical Manual of Mental Disordersfourth edition diagnoses of schizophrenia, and both sample sets were recruited according to the same protocol.
Handedness, brain asymmetry and schizophrenia are likely to be etiologically complex traits with several, or many, genetic and environmental influences.
Curr Opin Cell Biol. This was no more than the expected false-positive rate. Abnormalities of thalamic activation and cognition in schizophrenia. Leucine-rich repeat transmembrane neuronal protein vene.
RCSB PDB – Gene View – LRRTM1 – leucine rich repeat transmembrane neuronal 1
MGI integral component of postsynaptic specialization membrane Source: Unfortunately, it is not free lrrrm1 produce. Asymmetry of fetal cerebral hemispheres: The white signal in the dark-field images indicates Lrrtm1 expression. LRRTM1 is localized to the cell soma and in the neurites; in neurites it is also localized to lamellipodia of the growth cones arrowheads in h and i.
A further study in a larger Chinese sample will be required to distinguish these possibilities, together with identification of the functional variants in European populations.
Clyde Francks conceived and directed this research.
Leucine-rich repeat transmembrane neuronal protein 1
The black lines connecting boxes represent introns. Abnormalities of cerebral asymmetry are associated with schizophrenia and other neuropsychiatric disorders.
Each of the F1 mice was 30 weeks old. Database of Orthologous Groups More R-MMU Neurexins and neuroligins. However, we cannot rule out a subtle asymmetry of function or expression at some restricted time point during human brain development, as for the transcription factor LMO4.
We analyzed methylation within 2 CpG islands that correspond to the predicted promoter and coding exon of LRRTM1, and a third island roughly 18 kb upstream of LRRTM1, in 17 lymphoblastoid cell lines and 17 human post-mortem brain samples, but we did not find evidence that these CpG islands are differentially methylated regions DMRs data not shown.
Four distinct tokens exist: Database of comparative protein structure models More The algorithm is described in the ISO standard.
LRRTM1 – leucine rich repeat transmembrane neuronal 1
LRRTM1 is a candidate gene for involvement in several common neurodevelopmental disorders, and may have played a role in human cognitive and behavioral evolution. Support Center Support Center. CleanEx database of gene expression profiles More Endoplasmic reticulum endoplasmic reticulum Source: MGI integral component of membrane Source: From Wikipedia, the free encyclopedia.
These are stable lrrgm1 and should be used to cite UniProtKB entries. ProtoNet; Automatic hierarchical classification of proteins More However, this sample was not sufficiently large to test for heterogeneity of the association effect between lretm1 two patient groups. Kyoto Encyclopedia of Genes and Genomes More A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system.
EMBL nucleotide sequence database More Transport Classification Lrrtm11 More These results suggest that endogenous LRRTM1 may have a role in intracellular trafficking within axons. We also quantified left- and right-brain Lrrtm1 mRNA expression levels in rats and embryonic mice see Materials and methodsbut did not detect evidence for asymmetrical expression in rodents.
Mouse A9 cells containing single human chromosomes for analysis of genomic imprinting. Non-supervised Orthologous Groups More Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. Genome scan meta-analysis of schizophrenia and bipolar disorder, part Lrrt1 Corresponds to variant dbSNP: Select a section on the left to see content.
Search for genome features by name, symbol, synonym, homolog, allele, or accession ID: Supplementary Figure S2 jpeg 37K Click here to gwne.